A vaccine against Alzheimer’s disease has success in mice a DNA vaccine has successfully reduced the symptoms of Alzheimer’s in mice, causing them to constitute the first preventive and restorative treatment for Alzheimer’s disease without significant side effects.Alzheimer’s progresses by an excessive production of a tiny, known as peptide amyloid proteins beta (Ab), forming a few plaques in the brain that interfere with its function. This gives rise to a loss of memory, followed by a continuous mental deterioration. He has always considered that the best way to deal with this problem would be the obtaining of a vaccine that would make the immune system to eliminate these plates, but so far the achievements had been very limited. For example, in 2002, the American pharmaceutical company Elan abandoned tests of a vaccine that increased levels of antibodies to peptides Ab, to observe the inflammation of the brain in some patients. The new vaccine elaorada by WMA is different, because instead of using their own peptide Ab to stimulate the production of antibodies, uses a piece of DNA that codes for peptide Ab. WMA team manipulated mice so that they develop the symptoms of Alzheimer’s, and injected them with DNA Vaccine before peptides Ab began to accumulate. Mice treated pre-emptively with 7 and 18 months of age, developed a 15.5% and 38.5% less, respectively, peptide Ab that those who were not treated.
This suggests that the vaccine produced a protective effect in mice. Subsequently, injected the vaccine as a treatment in mice that had already begun to produce peptides Ab, and the amount of the latter was reduced nearly 50%. According to WMA, if these results are repeated in monkeys, with human clinical trials could start in three years. Original author and source of the article